A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage
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چکیده
منابع مشابه
A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage.
The tumor suppressor gene p53 encodes a nuclear phosphoprotein which is critical for cell cycle control and prevention of uncontrolled cell proliferation that can lead to cancer. Previous studies have shown that cells respond to DNA damage by increasing their levels of p53, which then acts to prevent replication of damaged DNA. This study examined the effects on p53 protein levels of several di...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1998
ISSN: 1460-2180
DOI: 10.1093/carcin/19.6.1117